I see that most people here are concluding that certain characters will be absent from MK10 based on the fact that they died in MK9's Story Mode.
You all seem to be overlooking one VERY important fact; Nobody ever really dies in Mortal Kombat. That is a direct quote from John Vogel, by the way...and last time I checked, it is Vogel who writes the MK story (a role he took over following the departure of John Tobias), so if you think that the likes of Sindel, Shang Tsung, Kung Lao, Liu Kang, Jax, Kitana, Jade, etc, are out of the question for MK10, you are sadly mistaken! Hell, Scorpion, arguably the foremost face of the MK franchise since its inception, has been dead since 2 years before the events of the first game, so what does that tell you about the finality of death in the Mortal Kombat franchise?
I'm aware of only one character who has been permanently killed off, and that is Hsu Hao.