Sindel's storyline begins tragically 10,000 years ago, when her kingdom was invaded by Shao Kahn, and she was forced to watch as her husband King Jerrod was killed, her people enslaved, herself becoming Kahn's wife, and then-infant Kitana adopted by Kahn as his daughter. This proved too much for her as a mother, wife, and queen, and soon after the invasion, she committed suicide.
However, this would not be the end of her. Gaining aid from the Elder God Shinnok, Shao Kahn would conspire to bring her back to life, but not in Outworld. Instead, her resurrection would take place on Earth, which would allow Shao Kahn to step through the borders separating the realms and claim her for himself, thus forcing a merger between Earth and Outworld. She would also be revived in a brainwashed state, with no knowledge of her past and having complete loyalty to her "husband" Kahn. After the sorcerer Shang Tsung failed to secure Earth via the Mortal Kombat tournament, Kahn implemented this plan, and was partially successful: Sindel was reborn just as was planned, and Kahn was able to garner a partial merger of the realms by her revival before Earth's warriors defeated him. However, Kahn didn't just lose Earth in his defeat; Kitana - realizing that her mother was alive - succeeded in procuring an audience with her and convincing her of her true past, thus turning Sindel against the emperor. As Kahn's defeat also succeeded in separating it from their homerealm of Edenia, Sindel took up her rightful place on its throne, and vowed not only to rebuild their home, but to also bring down Shao Kahn for his many crimes.
However, those plans had to wait, as one of Sindel's people, the daughter of an Edenian ambassador to the realms named Tanya, betrayed her homeland and allowed the Netherrealm forces of the fallen Elder God Shinnok to invade the palace. Though Kitana got away, Sindel herself was captured and held in her own dungeon until Shinnok's forces were defeated. Enraged at this latest invasion on her kingdom, Sindel sent Kitana to form an alliance with the Shokan armies and lead them into battle against a weakened Shao Kahn while she continued to help restore Edenia to its former beauty.
Unfortunately, Sindel's plans on restoring Edenia would once again have to wait. With the formantion of the Deadly Alliance, it brought conflict between Kitana and her alliance and they were slain in battle only to be later resurrected by Onaga the Dragon King as mindless warriors under his control. Edenia eventually fell to Onaga, and Sindel was locked away in one of her own palace dungeons with the brainwashed Kitana serving as her guard.
With the aid of the traitor, Tanya, he would begin to scour the kingdom for the missing Kamidogu, the sources of his true power. Luckily, Jade managed to defeat Kitana, free Sindel and escape with her to Outworld.
In Sindel's Armageddon ending, she defeats Blaze, and with the power of a god coursing through her, Sindel chooses to undo the murder of her husband Jerrod at Shao Kahn's hands. Reaching into the Heavens, she pulls his soul back to Edenia and makes him flesh once more. The reunited Jerrod, Sindel and Kitana form the Triad of the Just to protect the realms from tyrants like Shao Kahn.
, MK:A) 
