And weren't Mr. AND Mrs. Cage already konfirmed by that German GamePro mag that exposed Kano?
And Mileena might be sterile due to being a clone.
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Not sure how reliable that source is (plus would they really allow them to leak 4 characters?!). And the Ed Boon tweet can also mean she appears in story mode. I still think it would be unnecessary to feature Sonya in ladder with Cassie Cage being there, they might struggle to make 3 versions for her.
As for other descendants, I'm sure they will come up with at least one more, his original quotes implied that. They might be descendants of MK4-DA-D-A characters as well...