No, it won't be weird, because the game's plot will have nothing to do with the daggers at all. I wouldn't be surprised if they weren't even mentioned once.
What we're seeing in the comic is just a thing that happened in the universe of Mortal Kombat at some point. It seems like a big deal to us, because Shawn Kittelsen is doing a good job of connecting this to the MKX storyline by planting Reiko into the Mileena/Kotal Kahnflict, and by connecting the Kamidaggers to Raiden's attempt to lock Shinnok away.
I'd be glad to be wrong, I think Reiko could be a very fun character in this game.
Why do ppl insist on acting like their opinion are facts? How the do you know the daggers are not involved at all, psychic? Psycho?