I was contacted by Warner Brothers and asked to stop development, and take down the website.
I'm doing my own thing in Unreal Engine 4, and some are still working on this.
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Maya, 3dsMax, Blender and any like these, are all in one packages. You do like 80% of your work in them.
Zbrush, and Mudbox are for a more specific purpose, and that is to create high detail texture maps.
You can't do animation with Zbrush or Mudbox, you basically use them to make some cool looking models, and export them to Maya for example, to finish them off. That means, adding textures, animation, special effects, rendering, rigging, etc.
You can do a job with only Maya, or you can add Mudbox to your tool set, to make a better looking end product, add Photoshop and make it even better.
You should have both ideally, a general 3D application like Maya, a sculpting application like Mudbox, a photo editing application like Photoshop and maybe a application that is good with retopology, like 3Dcoat.
There are some alternate ways to get around the expensive applications.
Let's say, you get a copy of Maya, but can't afford Mudbox, or whatever else.
Use the sculpting tools in Blender, it's good and free.
If you can't get a strong retopology program, you can use the tools built in to Maya, 3dsMax, or the ones in Blender.
Just try to wiggle your way around and find what you need.
The combination I use mainly is...
3ds.Max (General needs, base mesh, rigging, animation, lighting, rendering..... It's the Main tool used)
Zbrush (Sculpting for normal and displacement maps, also helps with modeling)
3Dcoat (Retopology and Texture Painting)
Photoshop (Texture Painting)
Internet (Learning resource)